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Target
Reverse transcriptase
Ligand
BDBM50484288
Substrate
n/a
Meas. Tech.
ChEMBL_770448 (CHEMBL1833757)
IC50
547000±n/a nM
Citation
 Venkatraj, M; Ariën, KK; Heeres, J; Dirié, B; Joossens, J; Van Goethem, S; Van der Veken, P; Michiels, J; Vande Velde, CM; Vanham, G; Lewi, PJ; Augustyns, K Novel diarylpyridinones, diarylpyridazinones and diarylphthalazinones as potential HIV-1 nonnucleoside reverse transcriptase inhibitors (NNRTIs). Bioorg Med Chem 19:5924-34 (2011) [PubMed]  Article 
Target
Name:
Reverse transcriptase
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
29598.37
Organism:
Human immunodeficiency virus 1
Description:
Q9WKE8
Residue:
254
Sequence:
PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVN
  
Inhibitor
Name:
BDBM50484288
Synonyms:
CHEMBL1829447
Type:
Small organic molecule
Emp. Form.:
C20H19N5O
Mol. Mass.:
345.3978
SMILES:
Cc1cc(C)c(Nc2ccc(=O)n(Nc3ccc(cc3)C#N)n2)c(C)c1
Structure:
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