Reaction Details Report a problem with these data
Target
Metallo-beta-lactamase type 2
Ligand
BDBM50484376
Substrate
n/a
Meas. Tech.
ChEMBL_775599 (CHEMBL1913283)
Ki
29000±n/a nM
Citation
 Mohamed, MS; Hussein, WM; McGeary, RP; Vella, P; Schenk, G; Abd El-Hameed, RH Synthesis and kinetic testing of new inhibitors for a metallo-?-lactamase from Klebsiella pneumonia and Pseudomonas aeruginosa. Eur J Med Chem 46:6075-82 (2011) [PubMed]  Article 
Target
Name:
Metallo-beta-lactamase type 2
Synonyms:
B2 metallo-beta-lactamase | BLA-IMP | BLAB_SERMA | Beta-lactamase type II | IMP-1 | Metallo-beta-lactamase type II
Type:
undefined
Mol. Mass.:
27125.88
Organism:
Serratia marcescens
Description:
P52699
Residue:
246
Sequence:
MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN
  
Inhibitor
Name:
BDBM50484376
Synonyms:
CHEMBL1910739
Type:
Small organic molecule
Emp. Form.:
C28H19N5O
Mol. Mass.:
441.4834
SMILES:
[#6]-[#8]-c1ccc(cc1)-n1c2-[#7]=[#6]-[#7]\[#6](=[#6](\C#N)C#N)-c2c(c1-c1ccccc1)-c1ccccc1 |c:11|
Structure:
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