Reaction Details Report a problem with these data
Target
Metallo-beta-lactamase type 2
Ligand
BDBM50484531
Substrate
n/a
Meas. Tech.
ChEMBL_796098 (CHEMBL1936968)
Ki
16000±n/a nM
Citation
 Faridoon, na; Hussein, WM; Vella, P; Islam, NU; Ollis, DL; Schenk, G; McGeary, RP 3-mercapto-1,2,4-triazoles and N-acylated thiosemicarbazides as metallo-?-lactamase inhibitors. Bioorg Med Chem Lett 22:380-6 (2012) [PubMed]  Article 
Target
Name:
Metallo-beta-lactamase type 2
Synonyms:
B2 metallo-beta-lactamase | BLA-IMP | BLAB_SERMA | Beta-lactamase type II | IMP-1 | Metallo-beta-lactamase type II
Type:
undefined
Mol. Mass.:
27125.88
Organism:
Serratia marcescens
Description:
P52699
Residue:
246
Sequence:
MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN
  
Inhibitor
Name:
BDBM50484531
Synonyms:
CHEMBL1935524
Type:
Small organic molecule
Emp. Form.:
C15H12N4O4S
Mol. Mass.:
344.345
SMILES:
NC(=S)NNC(=O)c1ccc(cc1)C(=O)c1cccc(c1)[N+]([O-])=O
Structure:
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