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Target
Casein kinase II subunit alpha'/beta
Ligand
BDBM50484561
Substrate
n/a
Meas. Tech.
ChEMBL_794696 (CHEMBL1937305)
IC50
5.7±n/a nM
Citation
 Haddach, M; Pierre, F; Regan, CF; Borsan, C; Michaux, J; Stefan, E; Kerdoncuff, P; Schwaebe, MK; Chua, PC; Siddiqui-Jain, A; Macalino, D; Drygin, D; O'Brien, SE; Rice, WG; Ryckman, DM Synthesis and SAR of inhibitors of protein kinase CK2: novel tricyclic quinoline analogs. Bioorg Med Chem Lett 22:45-8 (2012) [PubMed]  Article 
Target
Name:
Casein kinase II subunit alpha'/beta
Synonyms:
Casein kinase II alpha''''/ beta | Casein kinase II alpha''/ beta | Casein kinase II alpha'/ beta
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 794696
Components:
This complex has 2 components.
Component 1
Name:
Casein kinase II subunit beta
Synonyms:
CK2N | CSK2B_HUMAN | CSNK2B | Casein kinase II subunit beta | Casein kinase II subunit beta (CK2 beta) | Casein kinase II subunit beta (CK2β) | G5A | Serine/threonine-protein kinase pim-2
Type:
Enzyme
Mol. Mass.:
24937.13
Organism:
Homo sapiens (Human)
Description:
P67870
Residue:
215
Sequence:
MSSSEEVSWISWFCGLRGNEFFCEVDEDYIQDKFNLTGLNEQVPHYRQALDMILDLEPDEELEDNPNQSDLIEQAAEMLYGLIHARYILTNRGIAQMLEKYQQGDFGYCPRVYCENQPMLPIGLSDIPGEAMVKLYCPKCMDVYTPKSSRHHHTDGAYFGTGFPHMLFMVHPEYRPKRPANQFVPRLYGFKIHPMAYQLQLQAASNFKSPVKTIR
  
Component 2
Name:
Casein kinase II subunit alpha'
Synonyms:
CK2A2 | CSK22_HUMAN | CSNK2A2 | Casein kinase II alpha (prime) | Casein kinase II alpha' | Casein kinase II subunit alpha (CK2A2) | Casein kinase II subunit alpha (CSNK2A2)
Type:
Protein
Mol. Mass.:
41223.82
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
350
Sequence:
MPGPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPCADNAVLSSGLTAAR
  
Inhibitor
Name:
BDBM50484561
Synonyms:
CHEMBL1934168
Type:
Small organic molecule
Emp. Form.:
C20H11F3N2O3
Mol. Mass.:
384.3081
SMILES:
OC(=O)c1ccc2c(c1)nc(-c1cccc(OC(F)(F)F)c1)c1ccncc21
Structure:
Search PDB for entries with ligand similarity: