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Target
Solute carrier family 22 member 8
Ligand
BDBM50103601
Substrate
n/a
Meas. Tech.
ChEMBL_838483 (CHEMBL2076054)
IC50
>2000000±n/a nM
Citation
 Jung, KY; Takeda, M; Shimoda, M; Narikawa, S; Tojo, A; Kim, DK; Chairoungdua, A; Choi, BK; Kusuhara, H; Sugiyama, Y; Sekine, T; Endou, H Involvement of rat organic anion transporter 3 (rOAT3) in cephaloridine-induced nephrotoxicity: in comparison with rOAT1. Life Sci 70:1861-74 (2002) [PubMed]  Article 
Target
Name:
Solute carrier family 22 member 8
Synonyms:
Oat3 | Organic anion transporter 3 | S22A8_RAT | Slc22a8 | rOat3
Type:
PROTEIN
Mol. Mass.:
59199.83
Organism:
Rattus norvegicus
Description:
ChEMBL_1482580
Residue:
536
Sequence:
MTFSEILDRVGSMGPFQYLHVTLLALPVLGIANHNLLQIFTATTPVHHCRPPPNASIGPWVLPLDPNGKPEKCLRFVHLPNASLPNDTQRATEPCLDGWIYNSTRDTIVIEWDLVCSSNKLKEMAQSIFMAGILVGGPVIGELSDRFGRKPILTWSYLMLAASGSGAAFSPSLPVYMIFRFLCGCSISGISLSTVILNVEWVPTSMRAISSTSIGYCYTIGQFILSGLAYAIPQWRWLQLTSSAPFFIFSLLSWWVPESIRWLVLSGKYSKALKTLQRVATFNGKKEEGKKLTIEELKFNLQKDITSAKVKYGLSDLFRVSILRRVTFCLSLAWFSTGFAYYSLAMGVEEFGVNIYILQIIFGGVDIPAKFITILSLSYLGRRITQSFLLLLAGGAILALIFVPSEMQLLRTALAVFGKGCLSGSFSCLFLYTSELYPTVLRQTGMGISNVWARVGSMIAPLVKITGELQPFIPNVIFGTTALLGGSAAFFLLETLNRPLPETIEDIQNWHKQVQKTKQESEAEKASQIIPLKTGG
  
Inhibitor
Name:
BDBM50103601
Synonyms:
CHEBI:29007 | Ceftriaxone
Type:
Small organic molecule
Emp. Form.:
C18H18N8O7S3
Mol. Mass.:
554.58
SMILES:
[H][C@@]1(NC(=O)C(=N/OC)\c2csc(N)n2)C(=O)N2C(C(O)=O)=C(CSc3nc(=O)c(O)nn3C)CS[C@]12[H] |t:22|
Structure:
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