Reaction Details Report a problem with these data
Target
Solute carrier family 22 member 5
Ligand
BDBM50485614
Substrate
n/a
Meas. Tech.
ChEMBL_836620 (CHEMBL2077361)
IC50
64000000±n/a nM
Citation
 Ganapathy, ME; Huang, W; Rajan, DP; Carter, AL; Sugawara, M; Iseki, K; Leibach, FH; Ganapathy, V beta-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter. J Biol Chem 275:1699-707 (2000) [PubMed]  Article 
Target
Name:
Solute carrier family 22 member 5
Synonyms:
High-affinity sodium-dependent carnitine cotransporter | OCTN2 | OCTN2_HUMAN | Organic cation/carnitine transporter 2 | SLC22A5 | Solute carrier family 22 member 5
Type:
PROTEIN
Mol. Mass.:
62756.52
Organism:
Homo sapiens
Description:
ChEMBL_104634
Residue:
557
Sequence:
MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLSSAWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIRKAAKANGIVVPSTIFDPSELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQMLRVKGMKHRKTPSHTRMLKDGQERPTILKSTAF
  
Inhibitor
Name:
BDBM50485614
Synonyms:
Cefoselis
Type:
Small organic molecule
Emp. Form.:
C19H22N8O6S2
Mol. Mass.:
522.558
SMILES:
[H][C@@]1(NC(=O)C(=N/OC)\c2csc(N)n2)C(=O)N2C(C([O-])=O)=C(C[n+]3ccc(N)n3CCO)CS[C@]12[H] |t:22|
Structure:
Search PDB for entries with ligand similarity: