Reaction Details Report a problem with these data
Target
Histone deacetylase 8
Ligand
BDBM50114826
Substrate
n/a
Meas. Tech.
ChEMBL_900186 (CHEMBL3047468)
IC50
450±n/a nM
Citation
  TBA Med Chem Res 21:568-577 (2012)    Article 
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM50114826
Synonyms:
8-(4-Methoxy-phenyl)-8-oxo-octanoic acid hydroxyamide | CHEMBL95835 | N-hydroxy-8-(4-methoxyphenyl)-8-oxooctanamide
Type:
Small organic molecule
Emp. Form.:
C15H21NO4
Mol. Mass.:
279.3315
SMILES:
COc1ccc(cc1)C(=O)CCCCCCC(=O)NO
Structure:
Search PDB for entries with ligand similarity: