Reaction Details Report a problem with these data
Target
Dihydrofolate reductase
Ligand
BDBM50029765
Substrate
n/a
Meas. Tech.
ChEMBL_52981 (CHEMBL876710)
IC50
190±n/a nM
Citation
 Queener, SF New drug developments for opportunistic infections in immunosuppressed patients: Pneumocystis carinii. J Med Chem 38:4739-59 (1996) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
DYR_PNECA | Dihydrofolate Reductase (DHFR) | Dihydrofolate reductase | Dihydrofolate reductase; P. carinii vs rat | Tetrahydrofolate dehydrogenase
Type:
Enzyme
Mol. Mass.:
23891.29
Organism:
Pneumocystis carinii
Description:
n/a
Residue:
206
Sequence:
MNQQKSLTLIVALTTSYGIGRSNSLPWKLKKEISYFKRVTSFVPTFDSFESMNVVLMGRKTWESIPLQFRPLKGRINVVITRNESLDLGNGIHSAKSLDHALELLYRTYGSESSVQINRIFVIGGAQLYKAAMDHPKLDRIMATIIYKDIHCDVFFPLKFRDKEWSSVWKKEKHSDLESWVGTKVPHGKINEDGFDYEFEMWTRDL
  
Inhibitor
Name:
BDBM50029765
Synonyms:
2-Chloro-5-(2,4-diamino-6-ethyl-pyrimidin-5-yl)-benzenediazonium | CHEMBL142345 | CHEMBL57222
Type:
Small organic molecule
Emp. Form.:
C12H12ClN6
Mol. Mass.:
275.716
SMILES:
CCc1nc(N)nc(N)c1-c1ccc(Cl)c(c1)[N+]#N
Structure:
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