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Target
Dihydrofolate reductase
Ligand
BDBM50029767
Substrate
n/a
Meas. Tech.
ChEMBL_55120 (CHEMBL665446)
IC50
18900±n/a nM
Citation
 Queener, SF New drug developments for opportunistic infections in immunosuppressed patients: Pneumocystis carinii. J Med Chem 38:4739-59 (1996) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
DYR_RAT | Dhfr | Dihydrofolate reductase (DHFR) | Dihydrofolate reductase; P. carinii vs rat | Tetrahydrofolate dehydrogenase
Type:
Enzyme
Mol. Mass.:
21638.84
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
187
Sequence:
MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD
  
Inhibitor
Name:
BDBM50029767
Synonyms:
5-{4-chloro-3-[(1E)-3-ethyltriaz-1-enyl]phenyl}-6-ethylpyrimidine-2,4-diamine | CHEMBL357573
Type:
Small organic molecule
Emp. Form.:
C14H18ClN7
Mol. Mass.:
319.793
SMILES:
CCN=NNc1cc(ccc1Cl)-c1c(N)nc(N)nc1CC |w:2.1|
Structure:
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