Reaction Details Report a problem with these data
Target
Protoporphyrinogen oxidase
Ligand
BDBM50487083
Substrate
n/a
Meas. Tech.
ChEMBL_907345 (CHEMBL3065646)
IC50
525±n/a nM
Citation
 Li, HB; Zhu, YQ; Song, XW; Hu, FZ; Liu, B; Li, YH; Niu, ZX; Liu, P; Wang, ZH; Song, HB; Zou, XM; Yang, HZ Novel protoporphyrinogen oxidase inhibitors: 3H-pyrazolo[3,4-d][1,2,3]triazin-4-one derivatives. J Agric Food Chem 56:9535-42 (2008) [PubMed]  Article 
Target
Name:
Protoporphyrinogen oxidase
Synonyms:
1.3.3.4 | Protoporphyrinogen oxidase
Type:
PROTEIN
Mol. Mass.:
56841.56
Organism:
Zea mays
Description:
ChEMBL_105521
Residue:
535
Sequence:
MVAATATAMATAASPLLNGTRIPARLRHRGLSVRCAAVAGGAAEAPASTGARLSADCVVVGGGISGLCTAQALATRHGVGDVLVTEARARPGGNITTVERPEEGYLWEEGPNSFQPSDPVLTMAVDSGLKDDLVFGDPNAPRFVLWEGKLRPVPSKPADLPFFDLMSIPGKLRAGLGALGIRPPPPGREESVEEFVRRNLGAEVFERLIEPFCSGVYAGDPSKLSMKAAFGKVWRLEETGGSIIGGTIKTIQERSKNPKPPRDARLPKPKGQTVASFRKGLAMLPNAITSSLGSKVKLSWKLTSITKSDDKGYVLEYETPEGVVSVQAKSVIMTIPSYVASNILRPLSSDAADALSRFYYPPVAAVTVSYPKEAIRKECLIDGELQGFGQLHPRSQGVETLGTIYSSSLFPNRAPDGRVLLLNYIGGATNTGIVSKTESELVEAVDRDLRKMLINSTAVDPLVLGVRVWPQAIPQFLVGHLDLLEAAKAALDRGGYDGLFLGGNYVAGVALGRCVEGAYESASQISDFLTKYAYK
  
Inhibitor
Name:
BDBM50487083
Synonyms:
CHEMBL2253455
Type:
Small organic molecule
Emp. Form.:
C17H15FN6O3
Mol. Mass.:
370.3378
SMILES:
Cc1nn(C)c2nnn(-c3cc4N(CC=C)C(=O)COc4cc3F)c(=O)c12
Structure:
Search PDB for entries with ligand similarity: