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Target
Peptidylglycine alpha-amidating monooxygenase
Ligand
BDBM50030352
Substrate
n/a
Meas. Tech.
ChEMBL_154488 (CHEMBL765265)
IC50
1600±n/a nM
Citation
 Erion, MD; Tan, J; Wong, M; Jeng, AY Inhibition of peptidylglycine alpha-amidating monooxygenase by N-substituted homocysteine analogs. J Med Chem 37:4430-7 (1995) [PubMed]  Article 
Target
Name:
Peptidylglycine alpha-amidating monooxygenase
Synonyms:
AMD_RAT | Pam | Peptidyl-glycine alpha-amidating monooxygenase
Type:
PROTEIN
Mol. Mass.:
108665.78
Organism:
Rattus norvegicus
Description:
ChEMBL_536304
Residue:
976
Sequence:
MAGRARSGLLLLLLGLLALQSSCLAFRSPLSVFKRFKETTRSFSNECLGTIGPVTPLDASDFALDIRMPGVTPKESDTYFCMSMRLPVDEEAFVIDFKPRASMDTVHHMLLFGCNMPSSTGSYWFCDEGTCTDKANILYAWARNAPPTRLPKGVGFRVGGETGSKYFVLQVHYGDISAFRDNHKDCSGVSVHLTRVPQPLIAGMYLMMSVDTVIPPGEKVVNADISCQYKMYPMHVFAYRVHTHHLGKVVSGYRVRNGQWTLIGRQNPQLPQAFYPVEHPVDVTFGDILAARCVFTGEGRTEATHIGGTSSDEMCNLYIMYYMEAKYALSFMTCTKNVAPDMFRTIPAEANIPIPVKPDMVMMHGHHKEAENKEKSALMQQPKQGEEEVLEQGDFYSLLSKLLGEREDVHVHKYNPTEKTESGSDLVAEIANVVQKKDLGRSDAREGAEHEEWGNAILVRDRIHRFHQLESTLRPAESRAFSFQQPGEGPWEPEPSGDFHVEEELDWPGVYLLPGQVSGVALDSKNNLVIFHRGDHVWDGNSFDSKFVYQQRGLGPIEEDTILVIDPNNAEILQSSGKNLFYLPHGLSIDTDGNYWVTDVALHQVFKLDPHSKEGPLLILGRSMQPGSDQNHFCQPTDVAVEPSTGAVFVSDGYCNSRIVQFSPSGKFVTQWGEESSGSSPRPGQFSVPHSLALVPHLDQLCVADRENGRIQCFKTDTKEFVREIKHASFGRNVFAISYIPGFLFAVNGKPYFGDQEPVQGFVMNFSSGEIIDVFKPVRKHFDMPHDIVASEDGTVYIGDAHTNTVWKFTLTEKMEHRSVKKAGIEVQEIKEAEAVVEPKVENKPTSSELQKMQEKQKLSTEPGSGVSVVLITTLLVIPVLVLLAIVMFIRWKKSRAFGDHDRKLESSSGRVLGRFRGKGSGGLNLGNFFASRKGYSRKGFDRVSTEGSDQEKDEDDGTESEEEYSAPLPKPAPSS
  
Inhibitor
Name:
BDBM50030352
Synonyms:
(S)-N-(3-Mercapto-propyl)-3-phenyl-2-(3-phenyl-propionylamino)-propionamide | CHEMBL335151
Type:
Small organic molecule
Emp. Form.:
C21H26N2O2S
Mol. Mass.:
370.508
SMILES:
SCCCNC(=O)[C@H](Cc1ccccc1)NC(=O)CCc1ccccc1
Structure:
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