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Target
1-aminocyclopropane-1-carboxylate synthase 5
Ligand
BDBM50487187
Substrate
n/a
Meas. Tech.
ChEMBL_908733 (CHEMBL3066160)
IC50
500±n/a nM
Citation
 Lin, LC; Hsu, JH; Wang, LC Identification of novel inhibitors of 1-aminocyclopropane-1-carboxylic acid synthase by chemical screening in Arabidopsis thaliana. J Biol Chem 285:33445-56 (2010) [PubMed]  Article 
Target
Name:
1-aminocyclopropane-1-carboxylate synthase 5
Synonyms:
1-aminocyclopropane-1-carboxylate synthase 5 | 1A15_ARATH | 4.4.1.14 | ACC synthase 5 | ACC5 | ACS5 | ETO2 | ETO2 | Ethylene-overproduction protein 2 | S-adenosyl-L-methionine methylthioadenosine-lyase 5
Type:
PROTEIN
Mol. Mass.:
53317.37
Organism:
Arabidopsis thaliana
Description:
ChEMBL_105532
Residue:
470
Sequence:
MKQLSTKVTSNGHGQDSSYFLGWEEYEKNPYDEIKNPNGMIQMGLAENQLCFDLIESWLTKNPDAASLKRNGQSIFRELALFQDYHGMPEFKKAMAEFMEEIRGNRVTFDPKKIVLAAGSTSANETLMFCLAEPGDAFLLPTPYYPGFDRDLKWRTGAEIVPIHCSSSNGFQITESALQQAYQQAQKLDLKVKGVLVTNPSNPLGTALTRRELNLLVDFITSKNIHLISDEIYSGTMFGFEQFISVMDVLKDKKLEDTEVSKRVHVVYSLSKDLGLPGFRVGAIYSNDEMIVSAATKMSSFGLVSSQTQYLLSALLSDKKFTSQYLEENQKRLKSRQRRLVSGLESAGITCLRSNAGLFCWVDMRHLLDTNTFEAELDLWKKIVYNVKLNISPGSSCHCTEPGWFRVCFANMSEDTLDLALKRLKTFVESTDCGRMISRSSHERLKSLRKKTVSNWVFRVSWTDRVPDER
  
Inhibitor
Name:
BDBM50487187
Synonyms:
CHEMBL2251967
Type:
Small organic molecule
Emp. Form.:
C21H19N3O2
Mol. Mass.:
345.3945
SMILES:
COc1ccc(cc1)C1CC(=O)c2cnc(Nc3ccccc3)nc2C1
Structure:
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