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Target
5-hydroxytryptamine receptor 6
Ligand
BDBM50537517
Substrate
n/a
Meas. Tech.
ChEMBL_1969940 (CHEMBL4602758)
IC50
3900±n/a nM
Citation
 Zhao, C; Rakesh, KP; Ravidar, L; Fang, WY; Qin, HL Pharmaceutical and medicinal significance of sulfur (S Eur J Med Chem 162:679-734 (2019) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 6
Synonyms:
5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46968.43
Organism:
Homo sapiens (Human)
Description:
P50406
Residue:
440
Sequence:
MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
  
Inhibitor
Name:
BDBM50537517
Synonyms:
CHEMBL4644799
Type:
Small organic molecule
Emp. Form.:
C22H22N4O2S2
Mol. Mass.:
438.566
SMILES:
CN1CCN(CC1)c1nc2cc(NS(=O)(=O)c3cccc4ccccc34)ccc2s1
Structure:
Search PDB for entries with ligand similarity: