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Target
RNA-directed RNA polymerase
Ligand
BDBM50379197
Substrate
n/a
Meas. Tech.
ChEMBL_1969960 (CHEMBL4602778)
IC50
8.0±n/a nM
Citation
 Ganta, NM; Gedda, G; Rathnakar, B; Satyanarayana, M; Yamajala, B; Ahsan, MJ; Jadav, SS; Balaraju, T A review on HCV inhibitors: Significance of non-structural polyproteins. Eur J Med Chem 164:576-601 (2019) [PubMed]  Article 
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
  
Inhibitor
Name:
BDBM50379197
Synonyms:
CHEMBL2011266
Type:
Small organic molecule
Emp. Form.:
C25H20F3N3O4S
Mol. Mass.:
515.504
SMILES:
Cc1cc2c(c(C(=O)NS(=O)(=O)C3CC3)n(Cc3cc(F)ccc3F)c2cc1F)-c1ccc[nH]c1=O |(35.01,-44.88,;36.34,-45.65,;37.67,-44.88,;39.01,-45.64,;40.48,-45.16,;41.39,-46.42,;42.74,-47.16,;44.06,-46.37,;42.76,-48.7,;44.11,-49.45,;44.87,-48.11,;45.65,-49.44,;44.13,-50.99,;43.39,-52.34,;44.93,-52.31,;40.48,-47.67,;41.29,-48.98,;40.56,-50.34,;39.02,-50.38,;38.29,-51.73,;36.75,-51.78,;39.1,-53.04,;40.65,-52.99,;41.37,-51.64,;42.91,-51.59,;39.01,-47.19,;37.68,-47.96,;36.34,-47.19,;35.01,-47.96,;41.25,-43.83,;40.48,-42.5,;41.23,-41.17,;42.78,-41.16,;43.56,-42.49,;42.79,-43.82,;43.57,-45.15,)|
Structure:
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