Reaction Details Report a problem with these data
Target
Proteinase-activated receptor 1
Ligand
BDBM50031386
Substrate
n/a
Meas. Tech.
ChEMBL_209246 (CHEMBL814873)
EC50
1500±n/a nM
Citation
 Feng, DM; Veber, DF; Connolly, TM; Condra, C; Tang, MJ; Nutt, RF Development of a potent thrombin receptor ligand. J Med Chem 38:4125-30 (1995) [PubMed]  Article 
Target
Name:
Proteinase-activated receptor 1
Synonyms:
CF2R | Coagulation factor II receptor | F2R | PAR-1 | PAR1 | PAR1_HUMAN | Proteinase activated receptor 1 | Proteinase-activated receptor 1 (PAR-1) | TR | Thrombin receptor | Thrombin receptor/ Proteinase-activated receptor 1(Par-1)
Type:
Protein
Mol. Mass.:
47450.07
Organism:
Homo sapiens (Human)
Description:
P25116
Residue:
425
Sequence:
MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEEKNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLNIMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTAAFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSSAVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVSSISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIYKKLLT
  
Inhibitor
Name:
BDBM50031386
Synonyms:
(S)-2-{(S)-2-[(S)-2-[(S)-2-((S)-2-Amino-propionylamino)-3-(3,4-dichloro-phenyl)-propionylamino]-3-(3,5-diiodo-4-methoxy-phenyl)-propionylamino]-3-cyclohexyl-propionylamino}-5-guanidino-pentanoic acid amide | CHEMBL334510
Type:
Small organic molecule
Emp. Form.:
C37H51Cl2I2N9O6
Mol. Mass.:
1042.572
SMILES:
COc1c(I)cc(C[C@H](NC(=O)[C@H](Cc2ccc(Cl)c(Cl)c2)NC(=O)[C@H](C)N)C(=O)N[C@@H](CC2CCCCC2)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O)cc1I
Structure:
Search PDB for entries with ligand similarity: