Reaction Details Report a problem with these data
Target
Acetylcholine receptor subunit alpha
Ligand
BDBM50078048
Substrate
n/a
Meas. Tech.
ChEMBL_915454 (CHEMBL3076138)
IC50
11000±n/a nM
Citation
 Tomizawa, M; Lee, DL; Casida, JE Neonicotinoid insecticides: molecular features conferring selectivity for insect versus mammalian nicotinic receptors. J Agric Food Chem 48:6016-24 (2000) [PubMed]  Article 
Target
Name:
Acetylcholine receptor subunit alpha
Synonyms:
ACHA_HUMAN | ACHRA | Acetylcholine receptor protein alpha chain | Acetylcholine receptor subunit alpha | CHNRA | CHRNA1 | Cholinergic, Nicotinic Alpha1Beta1DeltaGamma | Cholinergic, Nicotinic Alpha1Beta2 | Nicotinic acetylcholine receptor alpha-1/beta-1 | Nicotinic acetylcholine receptor alpha-1/beta-1/delta/epsilon | Nicotinic acetylcholine receptor alpha2/beta4 | alpha-1 Nicotinic AChR | n-AChR
Type:
Ion channel
Mol. Mass.:
54542.01
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
482
Sequence:
MEPWPLLLLFSLCSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRPSREKQDKKIFTEDIDISDISGKPGPPPMGFHSPLIKHPEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFAGRLIELNQQG
  
Inhibitor
Name:
BDBM50078048
Synonyms:
1-(6-Chloro-pyridin-3-ylmethyl)-imidazolidin-(2Z)-ylideneamine | 1-(6-Chloro-pyridin-3-ylmethyl)-imidazolidin-2-ylidene-ammonium | 1-(6-Chloro-pyridin-3-ylmethyl)-imidazolidin-2-ylideneamine | CHEMBL309804
Type:
Small organic molecule
Emp. Form.:
C9H11ClN4
Mol. Mass.:
210.663
SMILES:
NC1=NCCN1Cc1ccc(Cl)nc1 |t:1|
Structure:
Search PDB for entries with ligand similarity: