Reaction Details Report a problem with these data
Target
Deoxyhypusine synthase
Ligand
BDBM50032505
Substrate
n/a
Meas. Tech.
ChEMBL_53735 (CHEMBL663660)
IC50
556000±n/a nM
Citation
 Lee, YB; Park, MH; Folk, JE Diamine and triamine analogs and derivatives as inhibitors of deoxyhypusine synthase: synthesis and biological activity. J Med Chem 38:3053-61 (1995) [PubMed]  Article 
Target
Name:
Deoxyhypusine synthase
Synonyms:
DHYS_RAT | Dhps
Type:
PROTEIN
Mol. Mass.:
40696.63
Organism:
Rattus norvegicus
Description:
ChEMBL_53735
Residue:
369
Sequence:
MEGTPSGAAPSSALAAVLKHSSALPPESAQVQGYDFNRGVDYHALLEAYGTTGFQATNFGRAVQQVNAMIEKKLEPLAVDEDHHEDLTQSRRPLTGCTIFLGYTSNLISSGIRETIRYLVQHNMVDVLVTTAGGVEEDLIKCLAPTYLGEFSLRGKELRENGINRIGNLLVPNDNYCKFEDWLMPILDQMVQEQNTEGVKWTPSKMISRLGKEINNPESVYYWAHKNHIPVLSPALTDGSLGDMIFFHSYKNPGLVLDIVEDLRLINMQAIFAKRTGMIILGGGVVKHHIANANLMRNGADYAVYINTAQEFDGSDSGARPDEAVSWGKIRMDAQPVKVYADASLVFPLLVAETFAQKADAFRAEKNED
  
Inhibitor
Name:
BDBM50032505
Synonyms:
1,6,11-triazaundecane | CHEMBL36119 | N-(4-aminobutyl)-1,4-butanediamine | N-(4-aminobutyl)butane-1,4-diamine | bis(4-aminobutyl)amine | sym-homospermidine
Type:
Small organic molecule
Emp. Form.:
C8H21N3
Mol. Mass.:
159.2724
SMILES:
NCCCCNCCCCN
Structure:
Search PDB for entries with ligand similarity: