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Target
3-oxo-5-alpha-steroid 4-dehydrogenase 2
Ligand
BDBM50488077
Substrate
n/a
Meas. Tech.
ChEMBL_922089 (CHEMBL3078155)
IC50
0.500000±n/a nM
Citation
  TBA Med Chem Res 22:105-114 (2013)    Article 
Target
Name:
3-oxo-5-alpha-steroid 4-dehydrogenase 2
Synonyms:
3-oxo-5-alpha-steroid 4-dehydrogenase 2 | 5 alpha-SR2 | 5α-Reductase 2 (5α-R2) | S5A2_HUMAN | SR type 2 | SRD5A2 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 2 | Type II 5-alpha reductase
Type:
Enzyme
Mol. Mass.:
28406.59
Organism:
Homo sapiens (Human)
Description:
P31213
Residue:
254
Sequence:
MQVQCQQSPVLAGSATLVALGALALYVAKPSGYGKHTESLKPAATRLPARAAWFLQELPSFAVPAGILARQPLSLFGPPGTVLLGLFCLHYFHRTFVYSLLNRGRPYPAILILRGTAFCTGNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEISYRIPQGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFEDYPKSRKALIPFIF
  
Inhibitor
Name:
BDBM50488077
Synonyms:
CHEMBL2282764
Type:
Small organic molecule
Emp. Form.:
C36H43F3N2O2
Mol. Mass.:
592.734
SMILES:
CC(C)(C)c1ccc(cc1)-c1ccc(cc1NC(=O)[C@H]1CC[C@H]2[C@@H]3CNC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C)C(F)(F)F |r,t:28|
Structure:
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