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Target
Ecdysone receptor/Ultraspiracle
Ligand
BDBM50326777
Substrate
n/a
Meas. Tech.
ChEMBL_927359 (CHEMBL3073965)
IC50
437±n/a nM
Citation
 Tohidi-Esfahani, D; Lawrence, MC; Graham, LD; Hannan, GN; Simpson, AM; Hill, RJ Isoforms of the heteropteran Nezara viridula ecdysone receptor: protein characterisation, RH5992 insecticide binding and homology modelling. Pest Manag Sci 67:1457-67 (2011) [PubMed]  Article 
Target
Name:
Ecdysone receptor/Ultraspiracle
Synonyms:
Ecdysone receptor | Ecdysone receptor/Ultraspiracle isoform B
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 927359
Components:
This complex has 2 components.
Component 1
Name:
Ecdysone receptor
Synonyms:
Ecdysone receptor A isoform | Ecdysone receptor isoform A | LdEcR-A
Type:
PROTEIN
Mol. Mass.:
63442.81
Organism:
Leptinotarsa decemlineata
Description:
ChEMBL_106727
Residue:
565
Sequence:
MTTIHSITSHLGSMDIKHEMIYRDDDVLLVKSEPQLFTSNNGSITVSNLLSTSNFTTNTNNILVATTSNISSSNGLLLANNGLGNAGPFSGFNNSVVSVSQATKRQMTEDFMSSPSPGAISVSAPPLTPSPGPPSQPYTVISNGYSSPMSSGSYDPYSPNGKLGREDLSPPSSLNGFSADSCDAKKKKGPTPRQQEELCLVCGDRASGYHYNALTCEGCKGFFRRSVTKNAVYKCKYGANCEIDMYMRRKCQECRLKKCLAVGMRAECVVPEVQCAVKRNEKKKQKEKDKPNSTTNGSPEVIKIEPETLFFQLSENEKTIFNGVKPISPEQEELIHRLVYFQNEYEHPAEEDVKRIMNQPLESEDQCDVRFRHITEITILTVQLIVEFAKRLPGFDKLLREDQIALLKACSSEVMMFRMARRYDFQTDSILFVNNQPYSRDSYNLAGMGETIEDLLHFCRTMYSMKVDNAEYALLTAIVIFSERPALIEGWKVEKIQEIYLEALRAYVDNRRKPKPGTIFAKLLSVLTELRTLGNQNSEMCFSLKLKNKKLPPFLAEIWDVDMKT
  
Component 2
Name:
Ultraspiracle
Synonyms:
LdUSP | Ultraspiracle | Ultraspiracle isoform B
Type:
PROTEIN
Mol. Mass.:
43079.97
Organism:
Leptinotarsa decemlineata
Description:
ChEMBL_106727
Residue:
384
Sequence:
MGPLGPQSPMDIKPDASTLQFSPQGPNSPGSFSLGHANLLSPSPGGPKGVPNSPYPPNHPLSGSKHLCSICGDKASGKHYGVYSCEGCKGFFKRTVRKDLSYACREEKNCLIDKRQRNRCQYCRYQKCLVMGMKREAVQEERQRTKDRDASEVESTSSNPNEMSIERLLEAEKRVECNDPPVALENAVTNICQATNKQLLQLVEWAKLIPHFTSLPVSDQVLLLRAGWNELLIASFSHRSMQTQEGIILATGLTINKSTAQAVGVGNIYDRVLSELVNKMKEMRMDKTELGCLRAIILYNPDVRGLQSTQEVEILREKIYENLEEYTRTTHPNEPGRFAKLLLRLPALRSIGLKCLEHLFFFRLIGDVTIDTFITEMLENQSDT
  
Inhibitor
Name:
BDBM50326777
Synonyms:
(2beta,3beta,5beta,22R)-2,3,14,20,22,25-hexahydroxycholest-7-en-6-one | 20-hydroxyecdysone | CHEMBL224128
Type:
Small organic molecule
Emp. Form.:
C27H44O7
Mol. Mass.:
480.6341
SMILES:
CC(C)(O)CC[C@@H](O)[C@](C)(O)[C@H]1CC[C@@]2(O)C3=CC(=O)[C@@H]4C[C@@H](O)[C@@H](O)C[C@]4(C)[C@H]3CC[C@]12C |r,t:16|
Structure:
Search PDB for entries with ligand similarity: