Reaction Details Report a problem with these data
Target
Purine nucleoside phosphorylase
Ligand
BDBM50033665
Substrate
n/a
Meas. Tech.
ChEMBL_162188 (CHEMBL766708)
Ki
14000±n/a nM
Citation
 Kelley, JL; McLean, EW; Crouch, RC; Averett, DR; Tuttle, JV [[(Guaninylalkyl)phosphinico]methyl]phosphonic acids. Multisubstrate analogue inhibitors of human erythrocyte purine nucleoside phosphorylase. J Med Chem 38:1005-14 (1995) [PubMed]  Article 
Target
Name:
Purine nucleoside phosphorylase
Synonyms:
Inosine phosphorylase | Inosine-guanosine phosphorylase | NP | PNP | PNPH_HUMAN | Purine nucleoside phosphorylase (PNPase)
Type:
Enzyme
Mol. Mass.:
32119.53
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
289
Sequence:
MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS
  
Inhibitor
Name:
BDBM50033665
Synonyms:
CHEMBL268378 | {[5-(2-Amino-6-oxo-1,6-dihydro-purin-9-yl)-pentyl]-hydroxy-phosphinoylmethyl}-phosphonic acid monoethyl ester
Type:
Small organic molecule
Emp. Form.:
C13H23N5O6P2
Mol. Mass.:
407.2991
SMILES:
CCOP(O)(=O)CP(O)(=O)CCCCCn1cnc2c1nc(N)[nH]c2=O
Structure:
Search PDB for entries with ligand similarity: