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Target
D-alanine--D-alanine ligase
Ligand
BDBM7458
Substrate
n/a
Meas. Tech.
ChEMBL_931221 (CHEMBL3074976)
IC50
132700±n/a nM
Citation
  TBA Med Chem Res 22:2139-2150 (2013)    Article 
Target
Name:
D-alanine--D-alanine ligase
Synonyms:
6.3.2.4 | D-Ala-D-Ala ligase | D-alanine--D-alanine ligase | D-alanylalanine synthetase | DDL_HELPH | ddl
Type:
PROTEIN
Mol. Mass.:
39688.02
Organism:
Helicobacter pylori (strain HPAG1)
Description:
ChEMBL_106632
Residue:
347
Sequence:
MEFCVLFGGASFEHEISIVSAIALKGVLKDRIKYFIFLDENHHFYLIEASNMHSKYFAQIKEKKLPPLILTHKGLLKNSFLGAKIIELPLVINLVHGGDGEDGKLASLLEFYRIAFIGPRIEASVLSYNKYLTKLYAKDLGIKTLDHVLLNEKNRANAMDLINFNFPFIIKPNSAGSSLGVSVVKEEKELNYALDSAFEYSKEVLIEPFIQGVKEYNLAGCKIKKDFCFSYVEEPNKQEFLDFKQKYLDFSRTKAPKANLSNALEEQLKENFKKLYNDLFDGAIIRCDFFVIENEVYLNEINPIPGSLANYLFDDFKTTLENLAQSLPKTPKIQIKNSYLLQIQKNK
  
Inhibitor
Name:
BDBM7458
Synonyms:
5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one | 5,7-dihydroxy-2-(4-hydroxyphenyl)-chromen-4-one | Apigenin | Apigenin (2) | Apigenin (3) | Apigenin (7) | Apigenin, 13 | CHEMBL28 | Naringenin, 18 | US10278929, Apigenin | US11337935, Compound Apigenin | acs.jmedchem.1c00409_ST.789 | cid_5280443 | jm5b01461, Compound 90
Type:
Small organic molecule
Emp. Form.:
C15H10O5
Mol. Mass.:
270.2369
SMILES:
Oc1ccc(cc1)-c1cc(=O)c2c(O)cc(O)cc2o1
Structure:
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