Reaction Details
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Peroxisome proliferator-activated receptor alpha
Ligand
BDBM50269534
Substrate
n/a
Meas. Tech.
ChEMBL_933251 (CHEMBL3069175)
IC50
1400±n/a nM
Citation
TBA Med Chem Res 22:3126-3133 (2013) Article More Info.:
Target
Name:
Peroxisome proliferator-activated receptor alpha
Synonyms:
NR1C1 | Nuclear receptor subfamily 1 group C member 1 | PPAR | PPAR alpha/gamma | PPAR-alpha | PPARA | PPARA_HUMAN | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor alpha (PPAR alpha)
Type:
Enzyme
Mol. Mass.:
52222.08
Organism:
Homo sapiens (Human)
Description:
Q07869
Residue:
468
Sequence:
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
Inhibitor
Name:
BDBM50269534
Synonyms:
(8Z,11Z,14Z)-Icosatrienoic acid | (8Z,11Z,14Z)-icosa-8,11,14-trienoic acid | (Z,Z,Z)-8,11,14-Eicosatrienoate | (Z,Z,Z)-8,11,14-Eicosatrienoic acid | (Z,Z,Z)-8,11,14-Icosatrienoic acid | 8,11,14-Eicosatrienoate | 8,11,14-Eicosatrienoic Acid | 8,11,14-Icosatrienoate | CHEMBL465183 | DGLA | Dihomo-gamma-linolenic acid | Homo-gamma-linolenic acid | all-cis-icosa-8,11,14-trienoic acid | cis-8,11,14-eicosatrienoic acid | gamma-Homolinolenic acid
Type:
Small organic molecule
Emp. Form.:
C20H34O2
Mol. Mass.:
306.4828
SMILES:
CCCCC\C=C/C\C=C/C\C=C/CCCCCCC(O)=O
Structure:
