Reaction Details Report a problem with these data
Target
Adenosine receptor A1
Ligand
BDBM50034397
Substrate
n/a
Meas. Tech.
ChEMBL_29761 (CHEMBL636666)
Ki
16000±n/a nM
Citation
 Catarzi, D; Cecchi, L; Colotta, V; Filacchioni, G; Martini, C; Tacchi, P; Lucacchini, A Tricyclic heteroaromatic systems. Synthesis and A1 and A2a adenosine binding activities of some 1-aryl-1,4-dihydro-3-methyl[1]benzopyrano[2,3-c] pyrazol-4-ones, 1-aryl-4,9-dihydro-3-methyl-1H-pyrazolo[3,4-b]quinolin-4- ones, and 1-aryl-1H-imidazo[4,5-b]quinoxalines. J Med Chem 38:1330-6 (1995) [PubMed]  Article 
Target
Name:
Adenosine receptor A1
Synonyms:
AA1R_RAT | ADENOSINE A1 | ADENOSINE A1 high | ADENOSINE A1 low | Adenosine A1 receptor (A1) | Adenosine receptor | Adenosine receptors A1 | Adora1
Type:
Protein
Mol. Mass.:
36704.13
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
326
Sequence:
MPPYISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSVVEQDWRANGSVGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTFLKIWNDHFRCQPKPPIDEDLPEEKAED
  
Inhibitor
Name:
BDBM50034397
Synonyms:
1-(3-Amino-phenyl)-3-methyl-7-phenethyloxy-1H-chromeno[2,3-c]pyrazol-4-one | CHEMBL27431
Type:
Small organic molecule
Emp. Form.:
C25H21N3O3
Mol. Mass.:
411.4525
SMILES:
Cc1nn(-c2cccc(N)c2)c2oc3cc(OCCc4ccccc4)ccc3c(=O)c12
Structure:
Search PDB for entries with ligand similarity: