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Target
Neutrophil elastase
Ligand
BDBM50035534
Substrate
n/a
Meas. Tech.
ChEMBL_63962 (CHEMBL677431)
Ki
150000±n/a nM
Citation
 Burkhart, JP; Koehl, JR; Mehdi, S; Durham, SL; Janusz, MJ; Huber, EW; Angelastro, MR; Sunder, S; Metz, WA; Shum, PW Inhibition of human neutrophil elastase. 3. An orally active enol acetate prodrug. J Med Chem 38:223-33 (1995) [PubMed]  Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50035534
Synonyms:
(S)-1-{(S)-3-Methyl-2-[4-(morpholine-4-carbonyl)-benzoylamino]-butyryl}-pyrrolidine-2-carboxylic acid (3,3,4,4,4-pentafluoro-2-oxo-butyl)-amide | CHEMBL307227
Type:
Small organic molecule
Emp. Form.:
C26H31F5N4O6
Mol. Mass.:
590.5396
SMILES:
CC(C)[C@H](NC(=O)c1ccc(cc1)C(=O)N1CCOCC1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)C(F)(F)C(F)(F)F
Structure:
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