Reaction Details Report a problem with these data
Target
Adenosine receptor A2a
Ligand
BDBM50491094
Substrate
n/a
Meas. Tech.
ChEMBL_956569 (CHEMBL2380019)
Ki
1.4±n/a nM
Citation
 Shook, BC; Chakravarty, D; Barbay, JK; Wang, A; Leonard, K; Alford, V; Powell, MT; Rassnick, S; Scannevin, RH; Carroll, K; Wallace, N; Crooke, J; Ault, M; Lampron, L; Westover, L; Rhodes, K; Jackson, PF Substituted thieno[2,3-d]pyrimidines as adenosine A2A receptor antagonists. Bioorg Med Chem Lett 23:2688-91 (2013) [PubMed]  Article 
Target
Name:
Adenosine receptor A2a
Synonyms:
A2A adenosine receptor (hA2A) | AA2AR_HUMAN | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44716.46
Organism:
Homo sapiens (Human)
Description:
P29274
Residue:
412
Sequence:
MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
  
Inhibitor
Name:
BDBM50491094
Synonyms:
CHEMBL2377092
Type:
Small organic molecule
Emp. Form.:
C20H13ClN4S
Mol. Mass.:
376.862
SMILES:
Nc1nc(nc2sc(Cc3ccccc3Cl)cc12)-c1cccc(c1)C#N
Structure:
Search PDB for entries with ligand similarity: