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Target
Protein kinase C iota type
Ligand
BDBM139464
Substrate
n/a
Meas. Tech.
ChEMBL_963962 (CHEMBL2393914)
IC50
5000±n/a nM
Citation
 Titchenell, PM; Showalter, HD; Pons, JF; Barber, AJ; Jin, Y; Antonetti, DA Synthesis and structure-activity relationships of 2-amino-3-carboxy-4-phenylthiophenes as novel atypical protein kinase C inhibitors. Bioorg Med Chem Lett 23:3034-8 (2013) [PubMed]  Article 
Target
Name:
Protein kinase C iota type
Synonyms:
Atypical protein kinase C-lambda/iota | DXS1179E | KPCI_HUMAN | PRKC-lambda/iota | PRKCI | Protein kinase C (PKC) | Protein kinase C iota | Protein kinase C iota (PKCι) | Protein kinase C iota type | Protein kinase C iota type/zeta type | aPKC-lambda/iota | nPKC-iota
Type:
Enzyme
Mol. Mass.:
68251.56
Organism:
Homo sapiens (Human)
Description:
P41743
Residue:
596
Sequence:
MPTQRDSSTMSHTVAGGGSGDHSHQVRVKAYYRGDIMITHFEPSISFEGLCNEVRDMCSFDNEQLFTMKWIDEEGDPCTVSSQLELEEAFRLYELNKDSELLIHVFPCVPERPGMPCPGEDKSIYRRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKLVTIECGRHSLPQEPVMPMDQSSMHSDHAQTVIPYNPSSHESLDQVGEEKEAMNTRESGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLLMSAEECV
  
Inhibitor
Name:
BDBM139464
Synonyms:
US8889672, 194-074-007 | US8889672, PKCzI-diMeO
Type:
Small organic molecule
Emp. Form.:
C16H19NO4S
Mol. Mass.:
321.391
SMILES:
COc1ccc(cc1OC)-c1csc(N)c1C(=O)OC(C)C
Structure:
Search PDB for entries with ligand similarity: