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Target
Reverse transcriptase
Ligand
BDBM50492106
Substrate
n/a
Meas. Tech.
ChEMBL_969007 (CHEMBL2400596)
IC50
590±n/a nM
Citation
 Masaoka, T; Chung, S; Caboni, P; Rausch, JW; Wilson, JA; Taskent-Sezgin, H; Beutler, JA; Tocco, G; Le Grice, SF Exploiting drug-resistant enzymes as tools to identify thienopyrimidinone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H. J Med Chem 56:5436-45 (2013) [PubMed]  Article 
Target
Name:
Reverse transcriptase
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
29598.37
Organism:
Human immunodeficiency virus 1
Description:
Q9WKE8
Residue:
254
Sequence:
PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVN
  
Inhibitor
Name:
BDBM50492106
Synonyms:
CHEMBL2397401
Type:
Small organic molecule
Emp. Form.:
C17H18N2O3S
Mol. Mass.:
330.401
SMILES:
CCCc1c(CC)sc2nc([nH]c(=O)c12)-c1ccc(O)c(O)c1
Structure:
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