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Target
Tubulin beta chain
Ligand
BDBM50492298
Substrate
n/a
Meas. Tech.
ChEMBL_967216 (CHEMBL2400153)
IC50
3680±n/a nM
Citation
 Reddy, MV; Mallireddigari, MR; Pallela, VR; Cosenza, SC; Billa, VK; Akula, B; Subbaiah, DR; Bharathi, EV; Padgaonkar, A; Lv, H; Gallo, JM; Reddy, EP Design, synthesis, and biological evaluation of (E)-N-aryl-2-arylethenesulfonamide analogues as potent and orally bioavailable microtubule-targeted anticancer agents. J Med Chem 56:5562-86 (2013) [PubMed]  Article 
Target
Name:
Tubulin beta chain
Synonyms:
Beta-tubulin | TBB_PIG | Tubulin beta chain
Type:
PROTEIN
Mol. Mass.:
49840.26
Organism:
Sus scrofa
Description:
ChEMBL_105107
Residue:
445
Sequence:
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEEEGEEDEA
  
Inhibitor
Name:
BDBM50492298
Synonyms:
CHEMBL2397992
Type:
Small organic molecule
Emp. Form.:
C18H22N2O6S
Mol. Mass.:
394.442
SMILES:
COc1cc(OC)c(\C=C\S(=O)(=O)Nc2ccc(OC)c(N)c2)c(OC)c1
Structure:
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