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Target
Carbonic anhydrase 1
Ligand
BDBM50492481
Substrate
n/a
Meas. Tech.
ChEMBL_969520 (CHEMBL2406031)
Ki
8.7±n/a nM
Citation
 Güzel-Akdemir, Ö; Akdemir, A; Pan, P; Vermelho, AB; Parkkila, S; Scozzafava, A; Capasso, C; Supuran, CT A class of sulfonamides with strong inhibitory action against the ?-carbonic anhydrase from Trypanosoma cruzi. J Med Chem 56:5773-81 (2013) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 1
Synonyms:
CA-I | CA1 | CAB | CAH1_HUMAN | Carbonate dehydratase I | Carbonic anhydrase | Carbonic anhydrase 1 (CA I) | Carbonic anhydrase 1 (CA-I) | Carbonic anhydrase 1 (Recombinant CA I) | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase B | Carbonic anhydrase I | Carbonic anhydrase I (CA I) | Carbonic anhydrase I (CA-I) | Carbonic anhydrase I (CAI) | Carbonic anhydrase I (hCA I) | Carbonic anhydrase isoenzyme I (hCA I) | hCA
Type:
Enzyme
Mol. Mass.:
28873.37
Organism:
Homo sapiens (Human)
Description:
P00915
Residue:
261
Sequence:
MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF
  
Inhibitor
Name:
BDBM50492481
Synonyms:
CHEMBL2402754
Type:
Small organic molecule
Emp. Form.:
C15H15BrN2O4S
Mol. Mass.:
399.26
SMILES:
COc1ccc(CC(=O)Nc2ccc(cc2Br)S(N)(=O)=O)cc1
Structure:
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