Target
5-hydroxytryptamine receptor 6
Ligand
BDBM50029764
Substrate
n/a
Meas. Tech.
ChEMBL_975660 (CHEMBL2416144)
Ki
183±n/a nM
Citation
 Ivachtchenko, AGolovina, EKadieva, MMitkin, OTkachenko, SOkun, I Synthesis of substituted diphenyl sulfones and their structure-activity relationship with the antagonism of 5-??6 receptors. Bioorg Med Chem 21:4614-27 (2013) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 6
Synonyms:
5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46968.43
Organism:
Homo sapiens (Human)
Description:
P50406
Residue:
440
Sequence:
MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
  
Inhibitor
Name:
BDBM50029764
Synonyms:
1,1'-sulfonylbis(4-aminobenzene) | 4,4'-Sulfonylbisbenzenamine | 4,4'-dapsone | 4,4'-diaminodiphenyl sulfone | 4,4'-sulfonylbisaniline | 4,4'-sulfonyldianiline | 4-aminophenyl sulfone | Bis(p-aminophenyl) sulfone | CHEMBL1043 | DADPS | DAPSONE | DDS | Diaphenylsulfone | p,p'-diaminodiphenyl sulfone | p,p-sulphonylbisbenzamine | p,p-sulphonylbisbenzenamine | p-aminophenyl sulfone
Type:
Small organic molecule
Emp. Form.:
C12H12N2O2S
Mol. Mass.:
248.301
SMILES:
Nc1ccc(cc1)S(=O)(=O)c1ccc(N)cc1
Structure:
Search PDB for entries with ligand similarity: