Target
Dihydrofolate reductase
Ligand
BDBM50038261
Substrate
n/a
Meas. Tech.
ChEMBL_53626 (CHEMBL666655)
Kd
5100±n/a nM
Citation
 Ivery, MTGready, JE Structure-activity relationships and pH dependence of binding of 8-alkyl-N5-deazapterins to dihydrofolate reductase. J Med Chem 37:4211-21 (1995) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
1.5.1.3 | DHFR | DYR_CHICK
Type:
n/a
Mol. Mass.:
21652.69
Organism:
Gallus gallus (Chicken)
Description:
n/a
Residue:
189
Sequence:
VRSLNSIVAVCQNMGIGKDGNLPWPPLRNEYKYFQRMTSTSHVEGKQNAVIMGKKTWFSIPEKNRPLKDRINIVLSRELKEAPKGAHYLSKSLDDALALLDSPELKSKVDMVWIVGGTAVYKAAMEKPINHRLFVTRILHEFESDTFFPEIDYKDFKLLTEYPGVPADIQEEDGIQYKFEVYQKSVLAQ
  
Inhibitor
Name:
BDBM50038261
Synonyms:
2-Amino-5-methyl-8-propyl-2,8-dihydro-3H-pyrido[2,3-d]pyrimidin-4-one | CHEMBL340269
Type:
Small organic molecule
Emp. Form.:
C11H16N4O
Mol. Mass.:
220.2709
SMILES:
CCCN1C=CC(C)=C2C(=O)NC(N)N=C12 |c:4,t:7,14|
Structure:
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