Reaction Details
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Sodium- and chloride-dependent GABA transporter 2
Ligand
BDBM50492897
Substrate
n/a
Meas. Tech.
ChEMBL_975940 (CHEMBL2415589)
IC50
14454±n/a nM
Citation
Kowalczyk, P; Sa?at, K; Höfner, GC; Guzior, N; Filipek, B; Wanner, KT; Kulig, K 2-Substituted 4-hydroxybutanamides as potential inhibitors of ?-aminobutyric acid transporters mGAT1-mGAT4: synthesis and biological evaluation. Bioorg Med Chem 21:5154-67 (2013) [PubMed] Article More Info.:
Target
Name:
Sodium- and chloride-dependent GABA transporter 2
Synonyms:
GABA transporter | GABA transporter 3 | Gabt2 | Gabt3 | Gat-3 | Gat2 | Gat3 | S6A13_MOUSE | Slc6a13
Type:
PROTEIN
Mol. Mass.:
68283.40
Organism:
Mus musculus
Description:
ChEMBL_1460089
Residue:
602
Sequence:
MENRASGTTSNGETKPVCPAMEKVEEDGTLEREHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLIFLFTCGIPVFFLETALGQYTNQGGITAWRRICPIFEGIGYASQMIVSLLNVYYIVVLAWALFYLFSSFTTDLPWGSCSHEWNTENCVEFQKANDSMNVTSENATSPVIEFWERRVLKLSDGIQHLGSLRWELVLCLLLAWIICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLPGAAQGIQFYLYPNITRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCILNSSTSFMAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPRVFRKKNRREVLILIVSVISFFIGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGAGRFYDNIEDMIGYKPWPLIKYCWLFFTPAVCLATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALSSMICIPAWSIYKLRTLKGPLRERLRQLVCPAEDLPQKNQPEPTAPATPMTSLLRLTELESNC
Inhibitor
Name:
BDBM50492897
Synonyms:
CHEMBL2414179
Type:
Small organic molecule
Emp. Form.:
C29H34N2O2
Mol. Mass.:
442.5925
SMILES:
[#6]-[#7](-[#6]-[#6]\[#6]=[#6](/c1ccccc1)-c1ccccc1)-[#6](-[#6]-[#6]-[#8])-[#6](=O)-[#7]-[#6]-c1ccc(-[#6])cc1
Structure:
