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Target
Alpha-2A adrenergic receptor
Ligand
BDBM50027060
Substrate
n/a
Meas. Tech.
ChEMBL_986496 (CHEMBL2434577)
Ki
59±n/a nM
Citation
 Del Bello, F; Diamanti, E; Giannella, M; Mammoli, V; Mattioli, L; Titomanlio, F; Piergentili, A; Quaglia, W; Lanza, M; Sabatini, C; Caselli, G; Poggesi, E; Pigini, M Exploring multitarget interactions to reduce opiate withdrawal syndrome and psychiatric comorbidity. ACS Med Chem Lett 4:875-9 (2013) [PubMed]  Article 
Target
Name:
Alpha-2A adrenergic receptor
Synonyms:
ADA2A_HUMAN | ADRA2A | ADRA2R | ADRAR | Adrenergic alpha2A | Adrenergic receptor alpha | Alpha-2 adrenergic receptor subtype C10 | Alpha-2A adrenoceptor | Alpha-2A adrenoreceptor | Alpha-2AAR | alpha-2A adrenergic receptor [Homo sapiens]
Type:
Enzyme
Mol. Mass.:
48979.91
Organism:
Homo sapiens (Human)
Description:
P08913
Residue:
465
Sequence:
MFRQEQPLAEGSFAPMGSLQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVISAVISFPPLISIEKKGGGGGPQPAEPRCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDAVAAPPGGTERRPNGLGPERSAGPGGAEAEPLPTQLNGAPGEPAPAGPRDTDALDLEESSSSDHAERPPGPRRPERGPRGKGKARASQVKPGDSLPRRGPGATGIGTPAAGPGEERVGAAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV
  
Inhibitor
Name:
BDBM50027060
Synonyms:
2-(2-Cyclopropyl-phenoxymethyl)-4,5-dihydro-1H-imidazole | 2-(2-Cyclopropyl-phenoxymethyl)-4,5-dihydro-1H-imidazole (cirazoline) | CHEMBL13852 | CIRAZOLINE
Type:
Small organic molecule
Emp. Form.:
C13H16N2O
Mol. Mass.:
216.2789
SMILES:
C(Oc1ccccc1C1CC1)C1=NCCN1 |t:13|
Structure:
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