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Target
Protein kinase C delta type
Ligand
BDBM50493443
Substrate
n/a
Meas. Tech.
ChEMBL_985680 (CHEMBL2433611)
EC50
5.3±n/a nM
Citation
 Liang, X; Grue-Sørensen, G; Månsson, K; Vedsø, P; Soor, A; Stahlhut, M; Bertelsen, M; Engell, KM; Högberg, T Syntheses, biological evaluation and SAR of ingenol mebutate analogues for treatment of actinic keratosis and non-melanoma skin cancer. Bioorg Med Chem Lett 23:5624-9 (2013) [PubMed]  Article 
Target
Name:
Protein kinase C delta type
Synonyms:
KPCD_HUMAN | PKC delta | PKCD | PRKCD | Protein Kinase C- delta | Protein kinase C, PKC; classical/novel | nPKC-delta
Type:
Enzyme
Mol. Mass.:
77516.79
Organism:
Homo sapiens (Human)
Description:
The recombinant human PKC enzymes were produced using a baculovirus expression system in SF9 cells
Residue:
676
Sequence:
MAPFLRIAFNSYELGSLQAEDEANQPFCAVKMKEALSTERGKTLVQKKPTMYPEWKSTFDAHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLAERCKKNNGKAEFWLDLQPQAKVLMSVQYFLEDVDCKQSMRSEDEAKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEALNQVTQRASRRSDSASSEPVGIYQGFEKKTGVAGEDMQDNSGTYGKIWEGSSKCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGVTGNIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLSYSDKNLIDSMDQSAFAGFSFVNPKFEHLLED
  
Inhibitor
Name:
BDBM50493443
Synonyms:
CHEMBL2430141
Type:
Small organic molecule
Emp. Form.:
C26H36O6
Mol. Mass.:
444.5604
SMILES:
[H][C@@]12[#6]-[#6@@H](-[#6])[C@]34[#6]=[#6](-[#6])-[#6@H](-[#8]-[#6](=O)-[#6](\[#6])=[#6](\[#6])-[#6])[C@@]3([#8])[#6@H](-[#8])-[#6](-[#6]-[#8])=[#6][C@]([H])([#6]4=O)[C@]1([H])C2([#6])[#6] |r,c:25,t:6|
Structure:
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