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Target
Vesicular acetylcholine transporter
Ligand
BDBM50039604
Substrate
n/a
Meas. Tech.
ChEMBL_213554 (CHEMBL816914)
Ki
0.063±n/a nM
Citation
 Efange, SM; Khare, AB; Foulon, C; Akella, SK; Parsons, SM Spirovesamicols: conformationally restricted analogs of 2-(4-phenylpiperidino)cyclohexanol (vesamicol, AH5183) as potential modulators of presynaptic cholinergic function. J Med Chem 37:2574-82 (1994) [PubMed]  Article 
Target
Name:
Vesicular acetylcholine transporter
Synonyms:
TorVAChT | VACHT_TETCF | VAChT
Type:
PROTEIN
Mol. Mass.:
56111.93
Organism:
Torpedo californica
Description:
ChEMBL_1503355
Residue:
515
Sequence:
MGVTMAVGLAKAAMGKISSAIGERSKRISGAMNEPRRKRKILLVIVCIAMLLDNMLYMVIVPIIPNYLETIRTYKLVYITTPSNGTNGSLLNSTQRAVLERNPNANEDIQIGVLFASKAILQLLSNPFTGTFIDRVGYDIPLLIGLTIMFFSTITFAFGESYAVLFAARSLQGLGSAFADTSGIAMIADKYTEESERTQALGIALAFISFGSLVAPPFGGVLYQFAGKWVPFLVLSFVCLLDGILLLMVVTPFASRTRENMLQGTPIYKLMIDPYIAVVAGALTTCNIPLAFLEPTISNWMKKTMNASEWQMGITWLPAFFPHILGVYITVKLAAKYPNYQWFYGAVGLVIIGASSCTIPACRNFEELIIPLCALCFGIALVDTALLPTLAFLVDIRYVSVYGSVYAIADISYSVAYALGPIMAGQIVHDLGFVQLNLGMGLVNILYAPALLFLRNVCQMKPSLSERNILLEEGPKGLYDTIIMEERKAAKEPHGSSSGNHSVHAVLSDQEGYSE
  
Inhibitor
Name:
BDBM50039604
Synonyms:
(+)-1''-(3-Iodo-benzyl)-4-phenyl-[1,3'']bipiperidinyl-4''-ol | (-)-1''-(3-Iodo-benzyl)-4-phenyl-[1,3'']bipiperidinyl-4''-ol | (3''R,4''R)-1''-(3-Iodo-benzyl)-4-phenyl-[1,3'']bipiperidinyl-4''-ol | CHEMBL1204210 | CHEMBL50880 | trans-1-(3-iodobenzyl)-3-(4-phenylpiperidin-1-yl)piperidin-4-ol
Type:
Small organic molecule
Emp. Form.:
C23H29IN2O
Mol. Mass.:
476.3936
SMILES:
O[C@@H]1CCN(Cc2cccc(I)c2)C[C@H]1N1CCC(CC1)c1ccccc1
Structure:
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