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Target
D(2) dopamine receptor
Ligand
BDBM50040138
Substrate
n/a
Meas. Tech.
ChEMBL_59311 (CHEMBL666964)
IC50
3430±n/a nM
Citation
 Tupper, DE; Pullar, IA; Clemens, JA; Fairhurst, J; Risius, FC; Timms, GH; Wedley, S Synthesis and dopamine antagonist activity of 2-thioether derivatives of the ergoline ring system. J Med Chem 36:912-8 (1993) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
DOPAMINE D2 | DRD2 | DRD2_BOVIN | Dopamine D2 receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50698.79
Organism:
BOVINE
Description:
P20288
Residue:
444
Sequence:
MDPLNLSWYDDDPESRNWSRPFNGSEGKADRPPYNYYAMLLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPMLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRANLKAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKTVNPKIAKIFEIQSMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM50040138
Synonyms:
9-Methyl-5-methylsulfanyl-4,6,6a,7,8,10a-hexahydro-indolo[4,3-fg]quinoline | CHEMBL366850
Type:
Small organic molecule
Emp. Form.:
C16H18N2S
Mol. Mass.:
270.393
SMILES:
CSc1[nH]c2cccc3[C@H]4C=C(C)CN[C@@H]4Cc1c23 |t:10|
Structure:
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