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Target
Carbonic anhydrase 14
Ligand
BDBM50494702
Substrate
n/a
Meas. Tech.
ChEMBL_1279533 (CHEMBL3097252)
Ki
40±n/a nM
Citation
 Carroux, CJ; Rankin, GM; Moeker, J; Bornaghi, LF; Katneni, K; Morizzi, J; Charman, SA; Vullo, D; Supuran, CT; Poulsen, SA A prodrug approach toward cancer-related carbonic anhydrase inhibition. J Med Chem 56:9623-34 (2013) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 14
Synonyms:
CA-XIV | CA14 | CAH14_HUMAN | Carbonate dehydratase XIV | Carbonic Anhydrase XIV | Carbonic anhydrase | Carbonic anhydrase 14 | Carbonic anhydrase 14 (CA XIV) | Carbonic anhydrase XIV (CA XIV)
Type:
Enzyme
Mol. Mass.:
37665.67
Organism:
Homo sapiens (Human)
Description:
Human (cloned) isozyme.
Residue:
337
Sequence:
MLFSALLLEVIWILAADGGQHWTYEGPHGQDHWPASYPECGNNAQSPIDIQTDSVTFDPDLPALQPHGYDQPGTEPLDLHNNGHTVQLSLPSTLYLGGLPRKYVAAQLHLHWGQKGSPGGSEHQINSEATFAELHIVHYDSDSYDSLSEAAERPQGLAVLGILIEVGETKNIAYEHILSHLHEVRHKDQKTSVPPFNLRELLPKQLGQYFRYNGSLTTPPCYQSVLWTVFYRRSQISMEQLEKLQGTLFSTEEEPSKLLVQNYRALQPLNQRMVFASFIQAGSSYTTGEMLSLGVGILVGCLCLLLAVYFIARKIRKKRLENRKSVVFTSAQATTEA
  
Inhibitor
Name:
BDBM50494702
Synonyms:
CHEMBL3092940
Type:
Small organic molecule
Emp. Form.:
C34H50N4O11S
Mol. Mass.:
722.846
SMILES:
CC(C)CC(=O)OC[C@H]1O[C@H]([C@H](OC(=O)CC(C)C)[C@@H](OC(=O)CC(C)C)[C@@H]1OC(=O)CC(C)C)n1cc(nn1)-c1ccc(cc1)S(N)(=O)=O |r|
Structure:
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