Reaction Details Report a problem with these data
Target
Histone deacetylase 1
Ligand
BDBM50114826
Substrate
n/a
Meas. Tech.
ChEMBL_1280444 (CHEMBL3095756)
IC50
15±n/a nM
Citation
 Seo, YJ; Muench, L; Reid, A; Chen, J; Kang, Y; Hooker, JM; Volkow, ND; Fowler, JS; Kim, SW Radionuclide labeling and evaluation of candidate radioligands for PET imaging of histone deacetylase in the brain. Bioorg Med Chem Lett 23:6700-5 (2013) [PubMed]  Article 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM50114826
Synonyms:
8-(4-Methoxy-phenyl)-8-oxo-octanoic acid hydroxyamide | CHEMBL95835 | N-hydroxy-8-(4-methoxyphenyl)-8-oxooctanamide
Type:
Small organic molecule
Emp. Form.:
C15H21NO4
Mol. Mass.:
279.3315
SMILES:
COc1ccc(cc1)C(=O)CCCCCCC(=O)NO
Structure:
Search PDB for entries with ligand similarity: