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Target
Carbonic anhydrase 2
Ligand
BDBM50495073
Substrate
n/a
Meas. Tech.
ChEMBL_1282048 (CHEMBL3101837)
Ki
4.2±n/a nM
Citation
 Alafeefy, AM; Abdel-Aziz, HA; Vullo, D; Al-Tamimi, AM; Al-Jaber, NA; Capasso, C; Supuran, CT Inhibition of carbonic anhydrases from the extremophilic bacteria Sulfurihydrogenibium yellostonense (SspCA) and S. azorense (SazCA) with a new series of sulfonamides incorporating aroylhydrazone-, [1,2,4]triazolo[3,4-b][1,3,4]thiadiazinyl- or 2-(cyanophenylmethylene)-1,3,4-thiadiazol-3(2H)-yl moiet Bioorg Med Chem 22:141-7 (2014) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50495073
Synonyms:
CHEMBL3098135
Type:
Small organic molecule
Emp. Form.:
C13H9N5O3S2
Mol. Mass.:
347.372
SMILES:
[#6]-[#6](=O)-[#6]-1=[#7]-[#7](\[#6](-[#16]-1)=[#6](/C#N)C#N)-c1ccc(cc1)S([#7])(=O)=O |t:3|
Structure:
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