Reaction Details Report a problem with these data
Target
Sphingosine 1-phosphate receptor 4
Ligand
BDBM50495090
Substrate
n/a
Meas. Tech.
ChEMBL_1284416 (CHEMBL3106144)
EC50
3.6±n/a nM
Citation
 Deng, H; Bernier, SG; Doyle, E; Lorusso, J; Morgan, BA; Westlin, WF; Evindar, G Discovery of Clinical Candidate GSK1842799 As a Selective S1P1 Receptor Agonist (Prodrug) for Multiple Sclerosis. ACS Med Chem Lett 4:942-7 (2013) [PubMed]  Article 
Target
Name:
Sphingosine 1-phosphate receptor 4
Synonyms:
EDG6 | Endothelial differentiation G-protein coupled receptor 6 | S1P receptor 4 | S1P receptor Edg-6 | S1P4 | S1PR4 | S1PR4_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor Edg-6 | Sphingosine-1-phosphate receptor 4 | sphingosine-1-phosphate 4 S1P4
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
41647.39
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
384
Sequence:
MNATGTPVAPESCQQLAAGGHSRLIVLHYNHSGRLAGRGGPEDGGLGALRGLSVAASCLVVLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQWFLREGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGFIGLCWLLAALLGMLPLLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFAGVLATIMGLYGAIFRLVQASGQKAPRPAARRKARRLLKTVLMILLAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDWILALAVLNSAVNPIIYSFRSREVCRAVLSFLCCGCLRLGMRGPGDCLARAVEAHSGASTTDSSLRPRDSFRGSRSLSFRMREPLSSISSVRSI
  
Inhibitor
Name:
BDBM50495090
Synonyms:
CHEMBL3102903
Type:
Small organic molecule
Emp. Form.:
C21H30F3N2O5PS
Mol. Mass.:
510.507
SMILES:
CCCCCCCCOc1ccc(cc1C(F)(F)F)-c1cnc(s1)[C@@](C)(N)COP(O)(O)=O |r|
Structure:
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