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Target
Platelet-activating factor receptor
Ligand
BDBM50041924
Substrate
n/a
Meas. Tech.
ChEBML_151717
IC50
50±n/a nM
Citation
 Houlihan, WJ; Cheon, SH; Parrino, VA; Handley, DA; Larson, DA Structural modification of 5-aryl-2,3-dihydroimidazo[2,1-a]isoquinoline platelet activating factor receptor antagonists. J Med Chem 36:3098-102 (1993) [PubMed]  Article 
Target
Name:
Platelet-activating factor receptor
Synonyms:
PAF Platelet activating factor | PAF-R | PAFR | PTAFR | PTAFR_HUMAN | Platelet activating factor receptor | Platelet-activating factor receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39219.60
Organism:
Homo sapiens (Human)
Description:
PAF Platelet activating factor PTAFR HUMAN::P25105
Residue:
342
Sequence:
MEPHDSSHMDSEFRYTLFPIVYSIIFVLGVIANGYVLWVFARLYPCKKFNEIKIFMVNLTMADMLFLITLPLWIVYYQNQGNWILPKFLCNVAGCLFFINTYCSVAFLGVITYNRFQAVTRPIKTAQANTRKRGISLSLVIWVAIVGAASYFLILDSTNTVPDSAGSGNVTRCFEHYEKGSVPVLIIHIFIVFSFFLVFLIILFCNLVIIRTLLMQPVQQQRNAEVKRRALWMVCTVLAVFIICFVPHHVVQLPWTLAELGFQDSKFHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLTEKFYSMRSSRKCSRATTDTVTEVVVPFNQIPGNSLKN
  
Inhibitor
Name:
BDBM50041924
Synonyms:
7-Methyl-4-{4-[2-(3,4,5-trimethoxy-phenyl)-ethyl]-phenyl}-2,3-dihydro-6-oxa-1,3a-diaza-as-indacene | CHEMBL319921
Type:
Small organic molecule
Emp. Form.:
C27H28N2O4
Mol. Mass.:
444.5222
SMILES:
COc1cc(CCc2ccc(cc2)C2=Cc3oc(C)cc3C3=NCCN23)cc(OC)c1OC |t:14,23|
Structure:
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