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Target
Dihydrofolate reductase
Ligand
BDBM50042355
Substrate
n/a
Meas. Tech.
ChEBML_55129
IC50
36±n/a nM
Citation
 Gangjee, A; Shi, J; Queener, SF; Barrows, LR; Kisliuk, RL Synthesis of 5-methyl-5-deaza nonclassical antifolates as inhibitors of dihydrofolate reductases and as potential antipneumocystis, antitoxoplasma, and antitumor agents. J Med Chem 36:3437-43 (1993) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
DYR_RAT | Dhfr | Dihydrofolate reductase (DHFR) | Dihydrofolate reductase; P. carinii vs rat | Tetrahydrofolate dehydrogenase
Type:
Enzyme
Mol. Mass.:
21638.84
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
187
Sequence:
MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD
  
Inhibitor
Name:
BDBM50042355
Synonyms:
5-Methyl-6-{[methyl-(3,4,5-trichloro-phenyl)-amino]-methyl}-pyrido[2,3-d]pyrimidine-2,4-diamine | CHEMBL82924
Type:
Small organic molecule
Emp. Form.:
C16H15Cl3N6
Mol. Mass.:
397.69
SMILES:
CN(Cc1cnc2nc(N)nc(N)c2c1C)c1cc(Cl)c(Cl)c(Cl)c1
Structure:
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