Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50495575
Substrate
n/a
Meas. Tech.
ChEMBL_1290915 (CHEMBL3118888)
Ki
272±n/a nM
Citation
 Lacivita, E; Niso, M; Hansen, HD; Di Pilato, P; Herth, MM; Lehel, S; Ettrup, A; Montenegro, L; Perrone, R; Berardi, F; Colabufo, NA; Leopoldo, M; Knudsen, GM Design, synthesis, radiolabeling and in vivo evaluation of potential positron emission tomography (PET) radioligands for brain imaging of the 5-HT? receptor. Bioorg Med Chem 22:1736-50 (2014) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1A | 5-hydroxytryptamine receptor 1A (5-HT-1A) | 5HT1A_HUMAN | ADRB2RL1 | ADRBRL1 | Dopamine D2 receptor and serotonin 1a receptor | G-21 | HTR1A | Serotonin receptor 1A
Type:
n/a
Mol. Mass.:
46122.49
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
422
Sequence:
MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ
  
Inhibitor
Name:
BDBM50495575
Synonyms:
CHEMBL3113600
Type:
Small organic molecule
Emp. Form.:
C29H34FN3O3
Mol. Mass.:
491.597
SMILES:
COc1ccc(CNC(=O)CCOCCN2CCN(CC2)c2ccccc2-c2ccc(F)cc2)cc1
Structure:
Search PDB for entries with ligand similarity: