Reaction Details Report a problem with these data
Target
Lanosterol 14-alpha demethylase
Ligand
BDBM31653
Substrate
n/a
Meas. Tech.
ChEBML_96762
Ki
117±n/a nM
Citation
 Walker, KA; Kertesz, DJ; Rotstein, DM; Swinney, DC; Berry, PW; So, OY; Webb, AS; Watson, DM; Mak, AY; Burton, PM Selective inhibition of mammalian lanosterol 14 alpha-demethylase: a possible strategy for cholesterol lowering. J Med Chem 36:2235-7 (1993) [PubMed]  Article 
Target
Name:
Lanosterol 14-alpha demethylase
Synonyms:
CP51A_RAT | CYPLI | Cyp51 | Cyp51a1 | Cytochrome P450 51 | Cytochrome P450 51A1 | LDM | Lanosterol 14-alpha demethylase | P450-14DM | P45014DM | P450LI | Sterol 14-alpha demethylase
Type:
PROTEIN
Mol. Mass.:
56717.47
Organism:
Rattus norvegicus
Description:
ChEMBL_52075
Residue:
503
Sequence:
MVLLGLLQSGGSVLGQAMEQVTGGNLLSTLLIACAFTLSLVYLFRLAVGHMVQLPAGAKSPPYIYSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNEDLNAEEVYGRLTTPVFGKGVAYDVPNAVFLEQKKILKSGLNIAHFKQYVSIIEKEAKEYFKSWGESGERNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPSFRRRDRAHREIKNIFYKAIQKRRLSKEPAEDILQTLLDSTYKDGRPLTDDEIAGMLIGLLLAGQHTSSTTSAWMGFFLARDKPLQDKCYLEQKTVCGEDLPPLTYEQLKDLNLLDRCIKETLRLRPPIMTMMRMAKTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLINGYFPSVNYTTMIHTPENPVIRYKRRSK
  
Inhibitor
Name:
BDBM31653
Synonyms:
CHEMBL421109 | imidazole-dioxolane, 5
Type:
Small organic molecule
Emp. Form.:
C22H24ClN3O2S
Mol. Mass.:
429.963
SMILES:
Nc1ccc(SC[C@@H]2CO[C@@](CCc3ccc(Cl)cc3)(Cn3ccnc3)O2)cc1 |r|
Structure:
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