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Target
Aldo-keto reductase family 1 member B1
Ligand
BDBM50498161
Substrate
n/a
Meas. Tech.
ChEMBL_1469610 (CHEMBL3412867)
IC50
4181±n/a nM
Citation
 Qin, X; Hao, X; Han, H; Zhu, S; Yang, Y; Wu, B; Hussain, S; Parveen, S; Jing, C; Ma, B; Zhu, C Design and synthesis of potent and multifunctional aldose reductase inhibitors based on quinoxalinones. J Med Chem 58:1254-67 (2015) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
ALDR_RAT | Akr1b1 | Akr1b4 | Aldose reductase | Aldr1
Type:
PROTEIN
Mol. Mass.:
35797.87
Organism:
Rattus norvegicus
Description:
ChEMBL_1512484
Residue:
316
Sequence:
MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDMGYRHIDCAQVYQNEKEVGVALQEKLKEQVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGPDYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKPAVNQIECHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKEIAAKYNKTTAQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDFELSNEDMATLLSYNRNWRVCALMSCAKHKDYPFHAEV
  
Inhibitor
Name:
BDBM50498161
Synonyms:
CHEMBL3409368
Type:
Small organic molecule
Emp. Form.:
C19H16N2O4
Mol. Mass.:
336.3413
SMILES:
COc1ccc(\C=C\c2nc3ccccc3n(CC(O)=O)c2=O)cc1
Structure:
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