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Target
Chitinase
Ligand
BDBM50498224
Substrate
n/a
Meas. Tech.
ChEMBL_1495718 (CHEMBL3578791)
Ki
980±n/a nM
Citation
 Gooyit, M; Tricoche, N; Javor, S; Lustigman, S; Janda, KD Exploiting the Polypharmacology of ß-Carbolines to Disrupt O. volvulus Molting. ACS Med Chem Lett 6:339-43 (2015) [PubMed]  Article 
Target
Name:
Chitinase
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
55694.80
Organism:
Onchocerca volvulus
Description:
ChEMBL_1369100
Residue:
497
Sequence:
MRIGAMLIPFIILGNAIIAYGYVRGCYYTNWAQYRQGEGKFLPEDIPKGLCTHILYAFAKVDQSGTSLPFEWNDEDTNWSKGMYSRVTKLKENDPEMKILLSYGGYNFGSSTFTAIRNRAEKRKHFIKSAIAFLRKNKFDGFDFDWEYPIGMAQEYAKLVNEMKVAFVEEAKKSDSEQLLLTAAVSAGKHTIDQSYNVQSLGENFDLLSLMSYDFHGSWEMNVDLHAKLHPTKGETSGTGIFNTEFAANYWLSKGMPKQKIIIGIPTYGRGWTLRDSSKTTIGAEGISPSSPSTTNPAGGTAAYWEICKYLKEGGKETIDEQGVGACMVQGSQWYGYDNEETIRMKMRWLKEKGYGGAFIWTLDFDDFKGTSCGEGPYPLLSAINHELKGEATATTRSLRTTITQSSTIGSTKFETTTTASEITKNNKIKTTTIAVEPTGESSDIKCPESFGLFRHPNDCHLFIHCAHDHPYVKLCPPNTFFNDKIKVCDHFGECDE
  
Inhibitor
Name:
BDBM50498224
Synonyms:
CHEMBL3577757
Type:
Small organic molecule
Emp. Form.:
C26H21BrCl2N2O
Mol. Mass.:
528.268
SMILES:
[Br-].Cc1[n+](Cc2ccc(Cl)cc2)ccc2c1[nH]c1cc(OCc3ccc(Cl)cc3)ccc21
Structure:
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