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Target
Diacylglycerol O-acyltransferase 2
Ligand
BDBM360543
Substrate
n/a
Meas. Tech.
ChEMBL_1538840 (CHEMBL3737415)
IC50
180±n/a nM
Citation
 Imbriglio, JE; Shen, DM; Liang, R; Marby, K; You, M; Youm, HW; Feng, Z; London, C; Xiong, Y; Tata, J; Verras, A; Garcia-Calvo, M; Song, X; Addona, GH; McLaren, DG; He, T; Murphy, B; Metzger, DE; Salituro, G; Deckman, D; Chen, Q; Jin, X; Stout, SJ; Wang, SP; Wilsie, L; Palyha, O; Han, S; Hubbard, BK; Previs, SF; Pinto, S; Taggart, A Discovery and Pharmacology of a Novel Class of Diacylglycerol Acyltransferase 2 Inhibitors. J Med Chem 58:9345-53 (2015) [PubMed]  Article 
Target
Name:
Diacylglycerol O-acyltransferase 2
Synonyms:
ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | DGAT2_HUMAN | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase
Type:
Multi-pass membrane protein
Mol. Mass.:
43848.90
Organism:
Homo sapiens (Human)
Description:
Q96PD7
Residue:
388
Sequence:
MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN
  
Inhibitor
Name:
BDBM360543
Synonyms:
N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)spiro[2.5]octane-1- carboxamide | US9828369, Example 100
Type:
Small organic molecule
Emp. Form.:
C26H28N2O2
Mol. Mass.:
400.5127
SMILES:
COc1cccc(c1)-c1ccc(CNC(=O)C2CC22CCCCC2)c2cnccc12
Structure:
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