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Target
Acid ceramidase
Ligand
BDBM367199
Substrate
n/a
Meas. Tech.
ChEMBL_1542475 (CHEMBL3743922)
IC50
18±n/a nM
Citation
 Bach, A; Pizzirani, D; Realini, N; Vozella, V; Russo, D; Penna, I; Melzig, L; Scarpelli, R; Piomelli, D Benzoxazolone Carboxamides as Potent Acid Ceramidase Inhibitors: Synthesis and Structure-Activity Relationship (SAR) Studies. J Med Chem 58:9258-72 (2015) [PubMed]  Article 
Target
Name:
Acid ceramidase
Synonyms:
ASAH | ASAH1 | ASAH1_HUMAN | Acid ceramidase | Acid ceramidase (AC)
Type:
Enzyme
Mol. Mass.:
44662.65
Organism:
Homo sapiens (Human)
Description:
Q13510
Residue:
395
Sequence:
MPGRSCVALVLLAAAVSCAVAQHAPPWTEDCRKSTYPPSGPTYRGAVPWYTINLDLPPYKRWHELMLDKAPVLKVIVNSLKNMINTFVPSGKIMQVVDEKLPGLLGNFPGPFEEEMKGIAAVTDIPLGEIISFNIFYELFTICTSIVAEDKKGHLIHGRNMDFGVFLGWNINNDTWVITEQLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWILGKKDVMWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDRRTPAKMCLNRTSQENISFETMYDVLSTKPVLNKLTVYTTLIDVTKGQFETYLRDCPDPCIGW
  
Inhibitor
Name:
BDBM367199
Synonyms:
5,6-dichloro-2-oxo-N-(4- phenylbutyl)-1,3- benzoxazole-3-carboxamide | US10226452, Example 16
Type:
Small organic molecule
Emp. Form.:
C18H16Cl2N2O3
Mol. Mass.:
379.237
SMILES:
Clc1cc2oc(=O)n(C(=O)NCCCCc3ccccc3)c2cc1Cl
Structure:
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