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Target
Pancreatic alpha-amylase
Ligand
BDBM50499990
Substrate
n/a
Meas. Tech.
ChEMBL_1541281 (CHEMBL3742587)
IC50
12000±n/a nM
Citation
 Toh, ZS; Wang, H; Yip, YM; Lu, Y; Lim, BJ; Zhang, D; Huang, D Phenolic group on A-ring is key for dracoflavan B as a selective noncompetitive inhibitor of ?-amylase. Bioorg Med Chem 23:7641-9 (2015) [PubMed]  Article 
Target
Name:
Pancreatic alpha-amylase
Synonyms:
1,4-alpha-D-glucan glucanohydrolase | AMY2 | AMYP_PIG | Pancreatic α-amylase | Pancreatic α-amylase
Type:
Protein
Mol. Mass.:
57088.07
Organism:
Sus scrofa (Pig)
Description:
P00690
Residue:
511
Sequence:
MKLFLLLSAFGFCWAQYAPQTQSGRTSIVHLFEWRWVDIALECERYLGPKGFGGVQVSPPNENIVVTNPSRPWWERYQPVSYKLCTRSGNENEFRDMVTRCNNVGVRIYVDAVINHMCGSGAAAGTGTTCGSYCNPGNREFPAVPYSAWDFNDGKCKTASGGIESYNDPYQVRDCQLVGLLDLALEKDYVRSMIADYLNKLIDIGVAGFRIDASKHMWPGDIKAVLDKLHNLNTNWFPAGSRPFIFQEVIDLGGEAIQSSEYFGNGRVTEFKYGAKLGTVVRKWSGEKMSYLKNWGEGWGFMPSDRALVFVDNHDNQRGHGAGGASILTFWDARLYKVAVGFMLAHPYGFTRVMSSYRWARNFVNGQDVNDWIGPPNNNGVIKEVTINADTTCGNDWVCEHRWRQIRNMVWFRNVVDGQPFANWWANGSNQVAFGRGNRGFIVFNNDDWQLSSTLQTGLPGGTYCDVISGDKVGNSCTGIKVYVSSDGTAQFSISNSAEDPFIAIHAESKL
  
Inhibitor
Name:
BDBM50499990
Synonyms:
CHEMBL3740675
Type:
Small organic molecule
Emp. Form.:
C40H34O11
Mol. Mass.:
690.6914
SMILES:
[H][C@@]12[C@@H](O)[C@@](Oc3cc(OC(=O)c4cc(O)c(O)c(O)c4)c(C)c(OC)c13)(Oc1cc(OC)c3CC[C@H](Oc3c21)c1ccccc1)c1ccccc1 |r,THB:3:2:6.26.5:27.28.39|
Structure:
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