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Target
Tubulin beta chain
Ligand
BDBM50501218
Substrate
n/a
Meas. Tech.
ChEMBL_1617685 (CHEMBL3859754)
Kd
654000±n/a nM
Citation
 Ayoub, AT; Abou El-Magd, RM; Xiao, J; Lewis, CW; Tilli, TM; Arakawa, K; Nindita, Y; Chan, G; Sun, L; Glover, M; Klobukowski, M; Tuszynski, J Antitumor Activity of Lankacidin Group Antibiotics Is Due to Microtubule Stabilization via a Paclitaxel-like Mechanism. J Med Chem 59:9532-9540 (2016) [PubMed]  Article 
Target
Name:
Tubulin beta chain
Synonyms:
TBB5_HUMAN | TUBB | TUBB5 | TUBB5 | Tubulin beta chain | Tubulin beta-5 chain
Type:
PROTEIN
Mol. Mass.:
49650.12
Organism:
Homo sapiens
Description:
ChEMBL_117191
Residue:
444
Sequence:
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLDRISVYYNEATGGKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQVFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMAVTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEEDFGEEAEEEA
  
Inhibitor
Name:
BDBM50501218
Synonyms:
CHEMBL3917601
Type:
Small organic molecule
Emp. Form.:
C27H37NO8
Mol. Mass.:
503.5846
SMILES:
[H][C@]12C[C@H](OC(C)=O)\C=C\C(\C)=C\C[C@H](O)\C=C\C(\C)=C\[C@@H](NC(=O)C(C)O)[C@](C)(C(=O)O1)C(=O)[C@@H]2C |r,t:8,11,16,19|
Structure:
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